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Basic consideration of research strategies for head and neck cancer

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《医学前沿（英文）》 2012年第6卷第4期页码 339-353 doi: 10.1007/s11684-012-0213-7

摘要：

Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although the latter is often excluded and considered as part of endocrine neoplasms). Of these, 90% of HNCs are histologically squamous cell carcinomas originating from the mucosal lining. These malignancies are strongly associated with certain environmental and life-style risk factors, principally tobacco in both smoked and smokeless forms, excessive alcohol consumption, diets poor in antioxidants and essential micronutrients, UV light, chemicals used in certain workplaces, and viruses, principally certain strains of human papillomavirus (HPV) and Epstein-Barr virus (EBV). These cancers are frequently aggressive in their biological behaviour with local invasion and metastasis to lymph nodes in the neck. Since most patients are already at late stages of disease at the time of diagnosis, the desirable practice of early diagnosis (first sign of the malignant lesion at an initial stage ) and early treatment, a critical priority to save lives and retain quality of life, is difficult to implement. Thus, primary prevention has been set as a key goal. This article aims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head and neck cancer, basic features of clinical appearance of this group of cancers, and strategies for prevention and early detection. We also suggest basic research strategies on the basis of current knowledge, which should ultimately lead to the improvement of clinical management.

关键词： clinical management head and neck cancer prevention and early detection research strategies risk factors

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我国突发公共卫生事件应急防控体系建设研究

王卓然,李明穗,蒋慧莉,杨俊涛,杨维中,刘德培

《中国工程科学》 2021年第23卷第5期页码 18-23 doi: 10.15302/J-SSCAE-2021.05.003

摘要：

突发公共卫生事件严重危害人民生命健康，对国家安全、社会稳定和经济发展造成严重后果。本文在新型冠状病毒肺炎疫情应急背景下，从监测预警和评价、诊断与治疗、基础科学研究、人才教育培训、物质设备产业支撑和社会动员与协调行动六大体系分析我国突发公共卫生事件应急防控体系建设现状，指出强化体系建设是我国新发展阶段的现实需求。根据我国公共卫生体系建设在机构定位和能力建设、投入和支撑硬件、管理体系等方面存在的不足，提出建立国家统筹协调和应急指挥机制体系，强化临床、科技、教育、产业支撑能力及进一步推进国际合作等下一阶段加强我国突发公共卫生事件应急防控体系建设的建议。

关键词：突发公共卫生事件，防控体系，防治合一，检测预警，产业支撑

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Static-based early-damage detection using symbolic data analysis and unsupervised learning methods

João Pedro SANTOS,Christian CREMONA,André D. ORCESI,Paulo SILVEIRA,Luis CALADO

《结构与土木工程前沿（英文）》 2015年第9卷第1期页码 1-16 doi: 10.1007/s11709-014-0277-3

摘要： A large amount of researches and studies have been recently performed by applying statistical and machine learning techniques for vibration-based damage detection. However, the global character inherent to the limited number of modal properties issued from operational modal analysis may be not appropriate for early-damage, which has generally a local character. The present paper aims at detecting this type of damage by using static SHM data and by assuming that early-damage produces dead load redistribution. To achieve this objective a data driven strategy is proposed, consisting of the combination of advanced statistical and machine learning methods such as principal component analysis, symbolic data analysis and cluster analysis. From this analysis it was observed that, under the noise levels measured on site, the proposed strategy is able to automatically detect stiffness reduction in stay cables reaching at least 1%.

关键词： structural health monitoring early-damage detection principal component analysis symbolic data symbolic dissimilarity measures cluster analysis numerical model damage simulations

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A new and best approach for early detection of rotor and stator faults in induction motors coupled to

Abderrahim ALLAL,Boukhemis CHETATE

《能源前沿（英文）》 2016年第10卷第2期页码 176-191 doi: 10.1007/s11708-015-0386-2

摘要： Today, induction machines are playing, thanks to their robustness, an important role in world industries. Although they are quite reliable, they have become the target of various types of defects. Thus, for a long time, many research laboratories have been focusing their works on the theme of diagnosis in order to find the most efficient technique to predict a fault in an early stage and to avoid an unplanned stopping in the chain of production and costs ensuing. In this paper, an approach called Park’s vector product approach (PVPA) was proposed which was endowed with a dominant sensitivity in the case in which there would be rotor or stator faults. To show its high sensitivity, it was compared with the classical methods such as motor current signature analysis (MCSA) and techniques studied in recent publications such as motor square current signature analysis (MSCSA), Park’s vector square modulus (PVSM) and Park-Hilbert (P-H) (PVSM ). The proposed technique was based on three main steps. First, the three-phase currents of the induction motor led to a Park’s vector. Secondly, the proposed PVPA was calculated to show the distinguishing spectral signatures of each default and specific frequencies. Finally, simulation and experimental results were presented to confirm the theoretical assumptions.

关键词： induction motor incipient broken bar extended Park’s vector approach spectral analysis inter-turn short-circuit Hilbert transform

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早期监测肝细胞癌的新型非蛋白生物标志物 Review

Ghassan K. Abou-Alfa, 吴琳, Augusto Villanueva

《工程（英文）》 2021年第7卷第10期页码 1369-1374 doi: 10.1016/j.eng.2021.02.020

摘要：

肝细胞癌（HCC）早期检测是对处于早期阶段的肝细胞癌进行检出的方法，对降低高风险患者的HCC死亡率至关重要。然而，对于早期HCC，目前仍然缺乏具有高度灵敏性和特异性的监测生物标志物。近年来，人们对循环系统中可检测到的肿瘤源性分子特征进行了大量研究，比如循环肿瘤脱氧核糖核酸（ctDNA）和循环肿瘤核糖核酸（ctRNA），以探讨它们作为多种肿瘤类型的候选非侵入性生物标志物的潜力。本文汇总了目前有关早期HCC检测的新方法及应用的研究。

关键词：肝细胞癌早期检测生物标志物液体活检

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Low-dose CT for lung cancer screening: opportunities and challenges

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《医学前沿（英文）》 2018年第12卷第1期页码 116-121 doi: 10.1007/s11684-017-0600-1

摘要：

Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancer death in both males and females. Screening for lung cancer coupled with earlier intervention has long been studied as an approach to mortality reduction. However, minimal progress was achieved until recently, when low-dose spiral computed tomography (LDCT) screening demonstrated a 20% reduction in mortality from lung cancer in a randomized controlled trial (RCT), the National Lung Screening Trial, from the United States. On the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populations by several clinical guidelines. However, results from the following independent RCTs in Europe failed to show consistent conclusions. In addition, intractable problems gradually emerged with the progress of LDCT screening. This paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancer. Before spreading implementation of LDCT screening, challenges, including high false-positive rates, overdiagnosis, enormous costs, and radiation risk, must be addressed. Complementary biomarkers and technical improvement are expected in the field of lung cancer screening in the near future.

关键词： lung cancer low-dose computerized tomography early detection opportunities challenges

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

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《医学前沿（英文）》 2013年第7卷第4期页码 401-410 doi: 10.1007/s11684-013-0286-y

摘要：

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.

关键词： esophageal squamous cell carcinoma (ESCC) early detection molecular classification molecular markers

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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

《医学前沿（英文）》 2009年第3卷第3期页码 323-329 doi: 10.1007/s11684-009-0061-2

摘要： The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

关键词： early postmenopausal women bone mineral density exercise effects

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RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA

《农业科学与工程前沿（英文）》 2022年第9卷第1期页码 19-36 doi: 10.15302/J-FASE-2021411

摘要：

The importance of food security, especially in combating the problem of acute hunger, has been underscored as a key component of sustainable development. Considering the major challenge of rapidly increasing demands for both food security and safety, the management and control of major pests is urged to secure supplies of major agricultural products. However, owing to global climate change, biological invasion (e.g., fall armyworm), decreasing agricultural biodiversity, and other factors, a wide range of crop pest outbreaks are becoming more frequent and serious, making China, one of the world’s largest country in terms of agricultural production, one of the primary victims of crop yield loss and the largest pesticide consumer in the world. Nevertheless, the use of science and technology in monitoring and early warning of major crop pests provides better pest management and acts as a fundamental part of an integrated plant protection strategy to achieve the goal of sustainable development of agriculture. This review summarizes the most fundamental information on pest monitoring and early warning in China by documenting the developmental history of research and application, Chinese laws and regulations related to plant protection, and the National Monitoring and Early Warning System, with the purpose of presenting the Chinese model as an example of how to promote regional management of crop pests, especially of cross border pests such as fall armyworm and locust, by international cooperation across pest-related countries.

关键词： China / law / early warning system and national crop pest monitoring / pest management / regulation and sustainable agricultural development

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Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

《医学前沿（英文）》 2009年第3卷第2期页码 216-219 doi: 10.1007/s11684-009-0028-3

摘要： The purpose of this study was to investigate the expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion, and study the relationship of medical abortion through mifepristone and inducible nitric oxide synthase (iNOS) in early pregnancy. Expression of iNOS in trophoblasts and deciduas was detected by both hybridization and immunohistochemical assay in 40 patients (experimental group); the positive expression of iNOS was represented by number density (N/S) and positive unit (Pu) using computer color magic image analysis system (CMIAS). All results were compared with that obtained from vacuum aspiration. In the experimental group, N/S and Pu in trophoblasts were 0.120 ± 0.010 and 15.3 ± 2.6, respectively, while in the control group, they were 0.021 ± 0.003 and 3.1 ± 0.5, respectively, and there were significant differences between the two groups. By immunohistochemical assay, N/S and Pu were 0.090 ± 0.010, 10.24 ± 1.55 0.016 ± 0.002, 1.26 ± 0.33 in the trophoblasts of the two groups; there were also significant differences between the two groups. There were lower iNOS expressions in deciduas by in situ hybridization and immunohistochemical assay, and the difference between the two groups was not significant.It was concluded that mifepristone induced medical abortion through the expression of iNOS in trophoblasts but not in deciduas.

关键词： mifepristone inducible nitric oxide synthase early pregnancy placental immunity

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微生物安全产业发展策略研究

宋仲戬,李曼,胡梁斌,王春明,鲁曦,刘开辉,张丽佳,宇岩,吴清平

《中国工程科学》 2021年第23卷第5期页码 79-85 doi: 10.15302/J-SSCAE-2021.05.010

摘要：

微生物安全是新时期我国社会与经济健康发展的根本保障，是国家粮食安全、公共卫生、社会稳定的重要支撑。本文梳理了我国微生物安全产业发展面临的问题，结合微生物安全产业的政策环境，分析了微生物安全产业的发展需求和现状；在明晰微生物安全产业国内外发展格局的基础上，综合归纳了制约我国致病微生物检测与控制技术创新及应用研发的瓶颈，提出了构建我国微生物安全产业的发展规划。研究建议，强化微生物安全创新研究平台建设；构建微生物安全科学大数据库，以人才建设驱动能力提升；壮大微生物安全龙头企业，以标准规范保障产业发展；强化微生物安全领域的重大系统创新和工程技术研究，探索出我国微生物安全产业的高质量发展路径。

关键词：微生物安全微生物检测微生物诊断微生物防控核酸检测

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Role of chemerin/CMKLR1 in the maintenance of early pregnancy

Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing

《医学前沿（英文）》 2018年第12卷第5期页码 525-532 doi: 10.1007/s11684-017-0577-9

摘要：

Chemerin is a cytokine that attracts much attention in the reproductive process. This study aimed to explore the effects of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) on the maintenance of early pregnancy. The expression levels of chemerin and CMKLR1 in the decidua tissues of 20 early normal pregnant women and 20 early spontaneous abortion women were examined by Western blot and real-time polymerase chain reaction analyses. CMKLR1 receptor antagonist (α-NETA) was then intrauterinely injected into normal pregnant mice model to assess its effect on the outcome of pregnancy and the phosphorylation rate of ERK1/2 in decidua tissues. We found that the expression level of chemerin in women who had experienced early spontaneous abortion was lower than in those who had experienced normal early pregnancy (P<0.01); conversely, CMKLR1 expression was higher in the former than in the latter (P<0.01). In a pregnant-mouse model, the embryo resorption rate of α-NETA group was higher than that in the negative control group (61.5% vs. 10.8%) (P<0.001). Compared with the control group, ERK1/2 phosphorylation in decidua tissues decreased in the α-NETA-treated group (P<0.01). These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can lead to the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance of early pregnancy possibly by regulating ERK1/2 phosphorylation.

关键词： chemerin CMKLR1 early abortion

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Weak characteristic information extraction from early fault of wind turbine generator gearbox

Xiaoli XU, Xiuli LIU

《机械工程前沿（英文）》 2017年第12卷第3期页码 357-366 doi: 10.1007/s11465-017-0423-4

摘要：

Given the weak early degradation characteristic information during early fault evolution in gearbox of wind turbine generator, traditional singular value decomposition (SVD)-based denoising may result in loss of useful information. A weak characteristic information extraction based on µ-SVD and local mean decomposition (LMD) is developed to address this problem. The basic principle of the method is as follows: Determine the denoising order based on cumulative contribution rate, perform signal reconstruction, extract and subject the noisy part of signal to LMD and µ-SVD denoising, and obtain denoised signal through superposition. Experimental results show that this method can significantly weaken signal noise, effectively extract the weak characteristic information of early fault, and facilitate the early fault warning and dynamic predictive maintenance.

关键词： wind turbine generator gearbox µ-singular value decomposition local mean decomposition weak characteristic information extraction early fault warning

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Early-onset diabetes: an epidemic in China

Jiemin Pan, Weiping Jia

《医学前沿（英文）》 2018年第12卷第6期页码 624-633 doi: 10.1007/s11684-018-0669-1

摘要：

Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.

关键词： diabetes early-onset diabetes complications

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Biosensor-based assay of exosome biomarker for early diagnosis of cancer

《医学前沿（英文）》 2022年第16卷第2期页码 157-175 doi: 10.1007/s11684-021-0884-z

摘要： Cancer imposes a severe threat to people’s health and lives, thus pressing a huge medical and economic burden on individuals and communities. Therefore, early diagnosis of cancer is indispensable in the timely prevention and effective treatment for patients. Exosome has recently become an attractive cancer biomarker in noninvasive early diagnosis because of the unique physiology and pathology functions, which reflects remarkable information regarding the cancer microenvironment, and plays an important role in the occurrence and evolution of cancer. Meanwhile, biosensors have gained great attention for the detection of exosomes due to their superior properties, such as convenient operation, real-time readout, high sensitivity, and remarkable specificity, suggesting promising biomedical applications in the early diagnosis of cancer. In this review, the latest advances of biosensors regarding the assay of exosomes were summarized, and the superiorities of exosomes as markers for the early diagnosis of cancer were evaluated. Moreover, the recent challenges and further opportunities of developing effective biosensors for the early diagnosis of cancer were discussed.

关键词： biosensor exosome cancer diagnosis